Indigenous Peoples have experienced multiple forms of trauma for many generations that are still present today. The impact of colonizers’ attempts to rid Indigenous Peoples of their culture and identity led to experiences of colonial and historical trauma. This paper considers the necessary components of care for effective and accessible treatment and support for Indigenous Peoples with substance addiction. For resources to adequately support and treat concerns of Indigenous Peoples, necessary components of care need to be incorporated, such as providing trauma-informed care, culturally competent care, and equitably-oriented care. This paper is a literature review of those three components of care.