Using data collected through in-person interviews with a representative sample of 416 persons who are homeless in emergency shelters and drop-in centres in Ottawa, the paper presents results of a latent class analysis and a cluster analysis on a range of health-related variables. Results show that there are three distinct clusters of persons who are homeless characterized by different levels of severity of health problems. These clusters include an “economically disadvantaged” cluster of individuals relatively free of health difficulties (n = 232, 56%), another cluster with “substance abuse problems” (n = 103, 25%), and a third cluster with “health difficulties” (n = 80, 19%). Implications of these findings for policy and program planning are discussed