Epidemiologists, urban planners, and policy-makers have all sought to document and understand the links between cities and mental health. The day-to-day stresses of a big city, such as a high cost of living and a lack of affordable housing options, can undoubtedly take a toll on mental health. City-dwellers can face higher risks of mental health challenges including depression, anxiety, and post-traumatic stress disorder. At the same time, the rich social life of cities and the accessibility of essential services can be extremely beneficial. Cities provide diverse social, economic, and educational opportunities that can promote good health throughout the life course and strengthen peoples’ sense of well-being. Policy-makers in Toronto have an opportunity to take action to minimize the stress of city living while bolstering the aspects of the urban environment that support good mental health.