The mobility that is associated with homelessness creates various challenges to those endeavouring to contain a tuberculosis outbreak or otherwise manage the disease. It is argued that one important dimension missing from current tuberculosis management initiatives is an understanding of how the larger social context influences the mobility of the homeless and creates conditions that are conducive to the spread of this disease. I address this relationship by situating the experiences of the homeless in Toronto within a broader discussion of agency, structure, and the regulatory politics of mobility and place.