Fetal Alcohol Spectrum Disorder (FASD) is a multifaceted disability, associated not only with complex brain- and body-based challenges, but also with high rates of environmental adversity, diverse sociocultural contexts, and lifelong difficulties with daily living. It is important to consider the complexities of FASD, and the ways in which FASD requires unique considerations to develop and employ specialized research, practice, and policy initiatives in support of positive outcomes for individuals with FASD and their families.