Sociological theory portrays affiliation as an important source of personal power. Accordingly, some students of homelessness suggest that the extreme poverty and powerlessness of homeless individuals can be traced to a lack of social ties. Using data from a quota sample of 150 homeless persons in Birmingham, Alabama, this study examines (1) whether the homeless are disaffiliated and (2) the relationship between affiliation and power-related life experiences (personal efficacy). A 26-item scale measures affiliation; subscales assess expressive ties, instrumental supports, and acquaintances. Personal efficacy outcomes studied are depressive symptoms, anomie, mastery, physical and mental health, service knowledge, environmental satisfaction, and monthly income. Evidence suggests that many homeless persons have a network of confidants, friends, relatives, and acquaintances. However, these networks differ from those described in past research on general populations. Additionally, multiple regression results assign networks, at best, only modest effects on personal efficacy among the homeless.