This manuscript discusses how service providers can assist transgender youth in safely and successfully exiting homelessness.

Key Points:

• Transgender individuals experience high rates of violence,discrimination and homelessness.

• Psychiatric disorders should be managed before or concurrent with medical transition for gender dysphoria.

• Posttraumatic stress disorder (PTSD) can be a psychiatric comorbidity for transgender individuals who frequently experience recurrent trauma; intersectional oppression and social determinants of health need to be addressed for adequate treatment of PTSD.

• Addressing homelessness and other social determinants of health requires long-term engagement with interdisciplinary team support.

• Access to medical transition has been associated with significantly reduced suicidality.